5l42

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Current revision (16:06, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5l42' size='340' side='right'caption='[[5l42]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5l42' size='340' side='right'caption='[[5l42]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l42]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L42 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5L42 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l42]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L42 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6J6:(2~{R})-2-[3,4-BIS(OXIDANYL)PHENYL]-6-OXIDANYL-2,3-DIHYDROCHROMEN-4-ONE'>6J6</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6J6:(2~{R})-2-[3,4-BIS(OXIDANYL)PHENYL]-6-OXIDANYL-2,3-DIHYDROCHROMEN-4-ONE'>6J6</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l42 OCA], [https://pdbe.org/5l42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l42 RCSB], [https://www.ebi.ac.uk/pdbsum/5l42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l42 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5l42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l42 OCA], [http://pdbe.org/5l42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l42 RCSB], [http://www.ebi.ac.uk/pdbsum/5l42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l42 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTR1_LEIMA PTR1_LEIMA]] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).<ref>PMID:7972081</ref>
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[https://www.uniprot.org/uniprot/PTR1_LEIMA PTR1_LEIMA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).<ref>PMID:7972081</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pteridine reductase]]
 
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[[Category: Iacono, L Dello]]
 
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[[Category: Landi, G]]
 
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[[Category: Mangani, S]]
 
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[[Category: Pisa, F Di]]
 
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[[Category: Pozzi, C]]
 
[[Category: Leishmania major]]
[[Category: Leishmania major]]
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[[Category: Oxidoreductase]]
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[[Category: Dello Iacono L]]
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[[Category: Pteridine reductase 1]]
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[[Category: Di Pisa F]]
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[[Category: Ptr1]]
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[[Category: Landi G]]
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[[Category: Mangani S]]
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[[Category: Pozzi C]]

Current revision

Leishmania major Pteridine reductase 1 (PTR1) in complex with compound 3

PDB ID 5l42

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