5l8f

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Current revision (16:11, 4 October 2023) (edit) (undo)
 
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==Crystal structure of Rhodospirillum rubrum Rru_A0973 mutant E32A, E62A, H65A.==
==Crystal structure of Rhodospirillum rubrum Rru_A0973 mutant E32A, E62A, H65A.==
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<StructureSection load='5l8f' size='340' side='right' caption='[[5l8f]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='5l8f' size='340' side='right'caption='[[5l8f]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l8f]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhort Rhort]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L8F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l8f]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodospirillum_rubrum_ATCC_11170 Rhodospirillum rubrum ATCC 11170]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L8F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.247&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rru_A0973 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269796 RHORT])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l8f OCA], [http://pdbe.org/5l8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l8f RCSB], [http://www.ebi.ac.uk/pdbsum/5l8f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l8f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l8f OCA], [https://pdbe.org/5l8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l8f RCSB], [https://www.ebi.ac.uk/pdbsum/5l8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l8f ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FER_RHORT FER_RHORT] Cargo protein of a type 1 encapsulin nanocompartment. A ferritin-like ferroxidase that mineralizes iron inside the encapsulin nanocompartment. Converts Fe(2+) to Fe(3+) that is released to the exterior of the decameric complex for deposition in the encapsulin nanocompartment. In solution the decamer binds 10-15 iron cations; in the encapsulin nanocompartment the decamer can bind up to 48 ions, perhaps via its internal channel and on its exterior. The empty encapsulin nanocompartment sequesters about 2200 Fe ions while the cargo-loaded nanocompartment can maximally sequester about 4150 Fe ions. EncFtn retains ferroxidase activity when encapsulated (PubMed:27529188). Flux in the active site di-iron metal center is thought to be controlled by the 'entry site' of the protein, which both attracts metal and controls the rate of iron oxidation (Probable). Encapsulation in the nanocompartment does not alter either function of this protein (PubMed:32878987).<ref>PMID:27529188</ref> <ref>PMID:32878987</ref> <ref>PMID:32878987</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Rhort]]
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[[Category: Large Structures]]
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[[Category: Altenbach, K]]
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[[Category: Rhodospirillum rubrum ATCC 11170]]
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[[Category: Clarke, D J]]
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[[Category: Altenbach K]]
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[[Category: Georgiev, A]]
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[[Category: Clarke DJ]]
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[[Category: He, D]]
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[[Category: Georgiev A]]
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[[Category: Hughes, S]]
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[[Category: He D]]
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[[Category: Mackay, C L]]
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[[Category: Hughes S]]
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[[Category: Marles-Wright, J]]
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[[Category: Mackay CL]]
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[[Category: Tarrant, E]]
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[[Category: Marles-Wright J]]
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[[Category: Vanden-Hehir, S]]
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[[Category: Tarrant E]]
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[[Category: Waldron, K J]]
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[[Category: Vanden-Hehir S]]
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[[Category: Ferritin]]
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[[Category: Waldron KJ]]
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[[Category: Ferroxidase]]
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[[Category: Iron oxidation]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of Rhodospirillum rubrum Rru_A0973 mutant E32A, E62A, H65A.

PDB ID 5l8f

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