1nb4

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[[Image:1nb4.jpg|left|200px]]
[[Image:1nb4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1nb4 |SIZE=350|CAPTION= <scene name='initialview01'>1nb4</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1nb4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span>
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_1nb4| PDB=1nb4 | SCENE= }}
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|RELATEDENTRY=[[1nb6|1NB6]], [[1nb7|1NB7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nb4 OCA], [http://www.ebi.ac.uk/pdbsum/1nb4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nb4 RCSB]</span>
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}}
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'''HC-J4 RNA polymerase apo-form'''
'''HC-J4 RNA polymerase apo-form'''
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[[Category: Rowlands, D J.]]
[[Category: Rowlands, D J.]]
[[Category: Trowbridge, R.]]
[[Category: Trowbridge, R.]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: de-novo priming]]
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[[Category: De-novo priming]]
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[[Category: function analysis]]
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[[Category: Function analysis]]
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[[Category: hcv]]
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[[Category: Hcv]]
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[[Category: hepatitis c virus]]
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[[Category: Hepatitis c virus]]
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[[Category: ns5b]]
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[[Category: Ns5b]]
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[[Category: rdrp]]
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[[Category: Rdrp]]
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[[Category: replication]]
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[[Category: Replication]]
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[[Category: rna polymerase]]
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[[Category: Rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:19:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:27:58 2008''
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Revision as of 23:19, 2 May 2008

Image:1nb4.jpg

Template:STRUCTURE 1nb4

HC-J4 RNA polymerase apo-form


Overview

Several crystal structures of the hepatitis C virus NS5B protein (genotype-1b, strain J4) complexed with metal ions, single-stranded RNA or nucleoside-triphosphates have been determined. These complexes illustrate how conserved amino acid side-chains, together with essential structural features within the active site, control nucleotide binding and likely mediate de-novo initiation. The incoming nucleotide interacts with several basic residues from an extension on the NS5B fingers domain, a beta-hairpin from the NS5B thumb domain and the C-terminal arm. The modular, bi-partite fingers domain carries a long binding groove which guides the template towards the catalytic site. The apo-polymerase structure provides unprecedented insights into potential non-nucleoside inhibitor binding sites located between palm and thumb near motif E, which is unique to RNA polymerases and reverse transcriptases.

About this Structure

1NB4 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation., O'Farrell D, Trowbridge R, Rowlands D, Jager J, J Mol Biol. 2003 Feb 28;326(4):1025-35. PMID:12589751 Page seeded by OCA on Sat May 3 02:19:11 2008

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