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1nuh

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(New page: 200px<br /> <applet load="1nuh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nuh, resolution 2.51&Aring;" /> '''The crystal structu...)
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Revision as of 16:19, 12 November 2007

Image:1nuh.gif

1nuh, resolution 2.51Å

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The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate

Contents

Overview

Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate, metabolism that interconverts glucose 6-phosphate and fructose, 6-phosphate. Outside the cell, however, the protein appears to function as, a cytokine. A crystal structure of human PGI bound with, 5-phosphoarabinonate, a strong inhibitor that mimics the cis-enediol(ate), intermediate of the reaction, has been determined at 2.5 A resolution. The, structure helps to confirm the assignment of Glu357 as the base catalyst, in the isomerase reaction.

Disease

Known diseases associated with this structure: Hemolytic anemia due to glucosephosphate isomerase deficiency OMIM:[172400], Hydrops fetalis, one form OMIM:[172400]

About this Structure

1NUH is a Single protein structure of sequence from Homo sapiens with SO4 and PA5 as ligands. Active as Glucose-6-phosphate isomerase, with EC number 5.3.1.9 Full crystallographic information is available from OCA.

Reference

The structure of human phosphoglucose isomerase complexed with a transition-state analogue., Davies C, Muirhead H, Chirgwin J, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1111-3. Epub 2003, May 23. PMID:12777791

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