8b6m

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m (Protected "8b6m" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8b6m is ON HOLD until Paper Publication
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==Tankyrase 2 in complex with an inhibitor==
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<StructureSection load='8b6m' size='340' side='right'caption='[[8b6m]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Bosetti, C., Sowa, S.T., Lehtio, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8b6m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B6M FirstGlance]. <br>
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Description: Tankyrase 2 in complex with an inhibitor
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OY6:~{N}-(2-methoxyphenyl)-4-[[2-(4-oxidanylidene-3~{H}-quinazolin-2-yl)ethyl-(thiophen-2-ylmethyl)carbamoyl]amino]benzamide'>OY6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Sowa, S.T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b6m OCA], [https://pdbe.org/8b6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b6m RCSB], [https://www.ebi.ac.uk/pdbsum/8b6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b6m ProSAT]</span></td></tr>
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[[Category: Lehtio, L]]
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</table>
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[[Category: Bosetti, C]]
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== Function ==
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[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bosetti C]]
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[[Category: Lehtio L]]
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[[Category: Sowa ST]]

Revision as of 05:55, 11 October 2023

Tankyrase 2 in complex with an inhibitor

PDB ID 8b6m

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