6ds8

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Current revision (06:13, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6ds8' size='340' side='right'caption='[[6ds8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6ds8' size='340' side='right'caption='[[6ds8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ds8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DS8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ds8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DS8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MNH:MANGANESE+PROTOPORPHYRIN+IX'>MNH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mhuD, Rv3592 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MNH:MANGANESE+PROTOPORPHYRIN+IX'>MNH</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heme_oxygenase_(biliverdin-producing) Heme oxygenase (biliverdin-producing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.18 1.14.14.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ds8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ds8 OCA], [https://pdbe.org/6ds8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ds8 RCSB], [https://www.ebi.ac.uk/pdbsum/6ds8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ds8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ds8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ds8 OCA], [http://pdbe.org/6ds8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ds8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ds8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ds8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MHUD_MYCTU MHUD_MYCTU]] Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
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[https://www.uniprot.org/uniprot/MHUD_MYCTU MHUD_MYCTU] Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
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==See Also==
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Chao, A]]
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[[Category: Chao A]]
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[[Category: Goulding, C W]]
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[[Category: Goulding CW]]
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[[Category: Cell wall]]
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[[Category: Heme binding]]
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[[Category: Heme catabolic process]]
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[[Category: Metal ion binding]]
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[[Category: Monooxygenase activity]]
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[[Category: Oxidation reduction process]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase activity]]
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[[Category: Plasma membrane]]
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Current revision

Crystal structure of MhuD R26S mutant with two Manganese protoporphyrin IX bound per active site

PDB ID 6ds8

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