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6dtc

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Current revision (06:13, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6dtc' size='340' side='right'caption='[[6dtc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='6dtc' size='340' side='right'caption='[[6dtc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6dtc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DTC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6dtc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus_NRRL3357 Aspergillus flavus NRRL3357]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DTC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H9G:(3R)-3-methyl-4-[3-(1H-tetrazol-5-yl)phenoxy]-2,3-dihydrofuro[2,3-f]quinazoline-7,9-diamine'>H9G</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6drs|6drs]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H9G:(3R)-3-methyl-4-[3-(1H-tetrazol-5-yl)phenoxy]-2,3-dihydrofuro[2,3-f]quinazoline-7,9-diamine'>H9G</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dtc OCA], [http://pdbe.org/6dtc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dtc RCSB], [http://www.ebi.ac.uk/pdbsum/6dtc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dtc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dtc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dtc OCA], [https://pdbe.org/6dtc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dtc RCSB], [https://www.ebi.ac.uk/pdbsum/6dtc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dtc ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B8NBN5_ASPFN B8NBN5_ASPFN]
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspergillus flavus NRRL3357]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Akers-Rodriguez, S]]
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[[Category: Akers-Rodriguez S]]
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[[Category: Bensen, D C]]
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[[Category: Bensen DC]]
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[[Category: Fortier, J M]]
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[[Category: Fortier JM]]
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[[Category: Tari, L W]]
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[[Category: Tari LW]]
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[[Category: Antifolate]]
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[[Category: Antifungal protein]]
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[[Category: Antifungal protein-inhibitor complex]]
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[[Category: Dhfr]]
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Current revision

Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule inhibitor

PDB ID 6dtc

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