6e35

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Current revision (06:17, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6e35' size='340' side='right'caption='[[6e35]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='6e35' size='340' side='right'caption='[[6e35]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e35]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E35 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E35 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=ZCW:2-(1H-indol-3-yl)ethanol'>ZCW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.411&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDO1, IDO, INDO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=ZCW:2-(1H-indol-3-yl)ethanol'>ZCW</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indoleamine_2,3-dioxygenase Indoleamine 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.52 1.13.11.52] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e35 OCA], [https://pdbe.org/6e35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e35 RCSB], [https://www.ebi.ac.uk/pdbsum/6e35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e35 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e35 OCA], [http://pdbe.org/6e35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e35 RCSB], [http://www.ebi.ac.uk/pdbsum/6e35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e35 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN]] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
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[https://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Indoleamine 2,3-dioxygenase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Forouhar, F]]
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[[Category: Forouhar F]]
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[[Category: Hussain, M]]
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[[Category: Hussain M]]
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[[Category: Karkashon, S]]
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[[Category: Karkashon S]]
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[[Category: Lew, S]]
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[[Category: Lew S]]
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[[Category: Lewis-Ballester, A]]
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[[Category: Lewis-Ballester A]]
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[[Category: Lu, C]]
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[[Category: Lu C]]
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[[Category: Structural genomic]]
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[[Category: Seetharaman J]]
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[[Category: Seetharaman, J]]
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[[Category: Tong L]]
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[[Category: Tong, L]]
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[[Category: Yeh S-R]]
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[[Category: Yeh, S R]]
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[[Category: 3-dioxygenate]]
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[[Category: Nesg]]
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[[Category: Oxidoreductase]]
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[[Category: Psi-biology]]
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Current revision

Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160

PDB ID 6e35

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