This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6e5x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:19, 11 October 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='6e5x' size='340' side='right'caption='[[6e5x]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='6e5x' size='340' side='right'caption='[[6e5x]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6e5x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eboz5 Eboz5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E5X FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6e5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Zaire_(1995) Ebola virus - Zaire (1995)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E5X FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=128951 EBOZ5])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5x OCA], [http://pdbe.org/6e5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e5x RCSB], [http://www.ebi.ac.uk/pdbsum/6e5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5x ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5x OCA], [https://pdbe.org/6e5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e5x RCSB], [https://www.ebi.ac.uk/pdbsum/6e5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/VP30_EBOZ5 VP30_EBOZ5]] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity). [[http://www.uniprot.org/uniprot/RBBP6_HUMAN RBBP6_HUMAN]] E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
+
[https://www.uniprot.org/uniprot/RBBP6_HUMAN RBBP6_HUMAN] E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 6e5x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6e5x" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Eboz5]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Amarasinghe, G K]]
+
[[Category: Amarasinghe GK]]
-
[[Category: Leung, D W]]
+
[[Category: Leung DW]]
-
[[Category: Liu, D]]
+
[[Category: Liu D]]
-
[[Category: Small, G I]]
+
[[Category: Small GI]]
-
[[Category: Viral protein]]
+

Current revision

Crystal structure of Ebola virus VP30 C-terminus/RBBP6 peptide complex

PDB ID 6e5x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6e5x"
Personal tools