1ncv

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[[Image:1ncv.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ncv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ncv OCA], [http://www.ebi.ac.uk/pdbsum/1ncv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ncv RCSB]</span>
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'''DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES'''
'''DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES'''
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[[Category: Guillemot, J C.]]
[[Category: Guillemot, J C.]]
[[Category: Meunier, S.]]
[[Category: Meunier, S.]]
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[[Category: beta-chemokine]]
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[[Category: Beta-chemokine]]
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[[Category: chemotaxis]]
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[[Category: Chemotaxis]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: heparin-binding]]
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[[Category: Heparin-binding]]
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[[Category: mcp-3]]
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[[Category: Mcp-3]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: structure]]
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[[Category: Structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:22:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:28:37 2008''
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Revision as of 23:22, 2 May 2008

Image:1ncv.gif

Template:STRUCTURE 1ncv

DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES


Overview

MCP-3 is a beta chemokine consisting of 76 amino acid residues. It has been described to be involved in the activation of all leukocytic cells, activation mediated by the presence of multiple binding sites on the target cells. Its three-dimensional structure has been studied by making use of two-dimensional 1H NMR spectroscopy. MCP-3 exhibits the same monomeric structure as the other chemokines, i.e., a three-stranded antiparallel beta sheet covered on one face by an alpha helix. Although it belongs to the same subfamily as RANTES (Chung et al., 1995; Faitbrother et al., 1994) and hMIP-1beta (Lodi et al., 1994), the MCP-3 dimer is folded like IL-8 with the so-called alphabeta sandwich structural motif. Structural and sequence analysis gives clear indications suggesting that the other MCP chemokines may have the same quaternary structure, contrary to the other beta chemokines.

About this Structure

1NCV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy., Meunier S, Bernassau JM, Guillemot JC, Ferrara P, Darbon H, Biochemistry. 1997 Apr 15;36(15):4412-22. PMID:9109648 Page seeded by OCA on Sat May 3 02:22:57 2008

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