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6man
From Proteopedia
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==Crystal structure of a DnaN sliding clamp DNA polymerase III subunit beta from Rickettsia bellii RML369-C== | ==Crystal structure of a DnaN sliding clamp DNA polymerase III subunit beta from Rickettsia bellii RML369-C== | ||
| - | <StructureSection load='6man' size='340' side='right' caption='[[6man]], [[Resolution|resolution]] 2.35Å' scene=''> | + | <StructureSection load='6man' size='340' side='right'caption='[[6man]], [[Resolution|resolution]] 2.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6man]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MAN OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6man]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_bellii_RML369-C Rickettsia bellii RML369-C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MAN FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6man FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6man OCA], [https://pdbe.org/6man PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6man RCSB], [https://www.ebi.ac.uk/pdbsum/6man PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6man ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DPO3B_RICBR DPO3B_RICBR] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[UniProtKB:P0A988] |
| + | |||
| + | ==See Also== | ||
| + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rickettsia bellii RML369-C]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
| - | [[Category: Antibiotic]] | ||
| - | [[Category: Dnan]] | ||
| - | [[Category: Griselimycin]] | ||
| - | [[Category: National institute of allergy and infectious disease]] | ||
| - | [[Category: Niaid]] | ||
| - | [[Category: Polymerase]] | ||
| - | [[Category: Sliding clamp]] | ||
| - | [[Category: Ssgcid]] | ||
| - | [[Category: Structural genomoic]] | ||
| - | [[Category: Transcription]] | ||
Current revision
Crystal structure of a DnaN sliding clamp DNA polymerase III subunit beta from Rickettsia bellii RML369-C
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