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6mc1

From Proteopedia

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Current revision (06:28, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6mc1' size='340' side='right'caption='[[6mc1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='6mc1' size='340' side='right'caption='[[6mc1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mc1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MC1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MC1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mc1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MC1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CJA:3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one'>CJA</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP10, MKP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CJA:3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one'>CJA</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mc1 OCA], [http://pdbe.org/6mc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6mc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mc1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mc1 OCA], [https://pdbe.org/6mc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mc1 RCSB], [https://www.ebi.ac.uk/pdbsum/6mc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mc1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DUS10_HUMAN DUS10_HUMAN]] Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.<ref>PMID:22375048</ref>
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[https://www.uniprot.org/uniprot/DUS10_HUMAN DUS10_HUMAN] Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.<ref>PMID:22375048</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6mc1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6mc1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[MAP kinase phosphatase|MAP kinase phosphatase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Anderson, K S]]
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[[Category: Anderson KS]]
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[[Category: Bennett, A M]]
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[[Category: Bennett AM]]
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[[Category: Gannam, Z T.K]]
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[[Category: Gannam ZTK]]
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[[Category: Lolis, E]]
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[[Category: Lolis E]]
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[[Category: Dual specificity phosphatase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Phosphatase]]
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[[Category: Phosphatase-inhibitor complex]]
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[[Category: Protein-tyrosine phosphatase]]
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Current revision

Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1-((9-(methylthio)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl)thio)butan-2-one, an allosteric inhibitor

PDB ID 6mc1

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OCA

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