1nd2
From Proteopedia
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'''The structure of Rhinovirus 16''' | '''The structure of Rhinovirus 16''' | ||
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[[Category: Tull, T M.]] | [[Category: Tull, T M.]] | ||
[[Category: Zhang, Y.]] | [[Category: Zhang, Y.]] | ||
| - | [[Category: | + | [[Category: Hrv 16]] |
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | [[Category: | + | [[Category: Piconaviridae]] |
| - | [[Category: | + | [[Category: Pocket factor]] |
| - | [[Category: | + | [[Category: Rhinovirus]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:23:13 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 23:23, 2 May 2008
The structure of Rhinovirus 16
Overview
Pleconaril is a broad-spectrum antirhinovirus and antienterovirus compound that binds into a hydrophobic pocket within viral protein 1, stabilizing the capsid and resulting in the inhibition of cell attachment and RNA uncoating. When crystals of human rhinovirus 16 (HRV16) and HRV14 are incubated with pleconaril, drug occupancy in the binding pocket is lower than when pleconaril is introduced during assembly prior to crystallization. This effect is far more marked in HRV16 than in HRV14 and is more marked with pleconaril than with other compounds. These observations are consistent with virus yield inhibition studies and radiolabeled drug binding studies showing that the antiviral effect of pleconaril against HRV16 is greater on the infectivity of progeny virions than the parent input viruses. These data suggest that drug integration into the binding pocket during assembly, or at some other late stage in virus replication, may contribute to the antiviral activity of capsid binding compounds.
About this Structure
1ND2 is a Protein complex structure of sequences from Human rhinovirus 16. Full crystallographic information is available from OCA.
Reference
Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds., Zhang Y, Simpson AA, Ledford RM, Bator CM, Chakravarty S, Skochko GA, Demenczuk TM, Watanyar A, Pevear DC, Rossmann MG, J Virol. 2004 Oct;78(20):11061-9. PMID:15452226 Page seeded by OCA on Sat May 3 02:23:13 2008
