6mew

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Current revision (06:30, 11 October 2023) (edit) (undo)
 
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==RFXANK ankyrin repeats in complex with a RFX7 peptide==
==RFXANK ankyrin repeats in complex with a RFX7 peptide==
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<StructureSection load='6mew' size='340' side='right' caption='[[6mew]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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<StructureSection load='6mew' size='340' side='right'caption='[[6mew]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mew]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4qqm 4qqm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MEW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MEW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mew]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4qqm 4qqm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MEW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mew OCA], [http://pdbe.org/6mew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mew RCSB], [http://www.ebi.ac.uk/pdbsum/6mew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mew ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mew OCA], [https://pdbe.org/6mew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mew RCSB], [https://www.ebi.ac.uk/pdbsum/6mew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mew ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN]] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9806546</ref> <ref>PMID:10072068</ref> <ref>PMID:10725724</ref>
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[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9806546</ref> <ref>PMID:10072068</ref> <ref>PMID:10725724</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN]] Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
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[https://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN] Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Dong, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Li, Y]]
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[[Category: Dong A]]
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[[Category: Min, J]]
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[[Category: Edwards AM]]
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[[Category: Structural genomic]]
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[[Category: Li Y]]
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[[Category: Tempel, W]]
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[[Category: Min J]]
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[[Category: Xu, C]]
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[[Category: Tempel W]]
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[[Category: Ankyrin repeat]]
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[[Category: Xu C]]
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[[Category: Dna binding protein]]
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[[Category: Sgc]]
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Current revision

RFXANK ankyrin repeats in complex with a RFX7 peptide

PDB ID 6mew

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