6mha

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Current revision (06:31, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6mha' size='340' side='right'caption='[[6mha]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='6mha' size='340' side='right'caption='[[6mha]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mha]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MHA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MHA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mha]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MHA FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.497&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kne|1kne]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Su(var)205, HP1, CG8409 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mha OCA], [https://pdbe.org/6mha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mha RCSB], [https://www.ebi.ac.uk/pdbsum/6mha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mha ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mha OCA], [http://pdbe.org/6mha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mha RCSB], [http://www.ebi.ac.uk/pdbsum/6mha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mha ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HP1_DROME HP1_DROME]] Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
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[https://www.uniprot.org/uniprot/HP1_DROME HP1_DROME] Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Albanese, K I]]
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[[Category: Albanese KI]]
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[[Category: Brustad, E M]]
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[[Category: Brustad EM]]
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[[Category: Krone, M W]]
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[[Category: Krone MW]]
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[[Category: Waters, M L]]
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[[Category: Waters ML]]
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[[Category: Cation-pi epigenetics trimethyllysine chromodomain]]
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[[Category: Protein binding]]
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Current revision

dHP1 Chromodomain Y24W variant bound to histone H3 peptide containing trimethyllysine

PDB ID 6mha

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