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| | <StructureSection load='6mky' size='340' side='right'caption='[[6mky]], [[Resolution|resolution]] 2.90Å' scene=''> | | <StructureSection load='6mky' size='340' side='right'caption='[[6mky]], [[Resolution|resolution]] 2.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6mky]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MKY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6mky]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MKY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPP1R7, SDS22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mky OCA], [http://pdbe.org/6mky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mky RCSB], [http://www.ebi.ac.uk/pdbsum/6mky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mky ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mky OCA], [https://pdbe.org/6mky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mky RCSB], [https://www.ebi.ac.uk/pdbsum/6mky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mky ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PP1R7_HUMAN PP1R7_HUMAN]] Regulatory subunit of protein phosphatase 1. | + | [https://www.uniprot.org/uniprot/PP1R7_HUMAN PP1R7_HUMAN] Regulatory subunit of protein phosphatase 1. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 6mky" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 6mky" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Bolik-Coulon, N]] | + | [[Category: Bolik-Coulon N]] |
| - | [[Category: Choy, M S]] | + | [[Category: Choy MS]] |
| - | [[Category: Page, R]] | + | [[Category: Page R]] |
| - | [[Category: Peti, W]] | + | [[Category: Peti W]] |
| - | [[Category: Cell cycle]]
| + | |
| - | [[Category: Lrr repeat]]
| + | |
| - | [[Category: Pp1]]
| + | |
| - | [[Category: Sds22]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| Structural highlights
Function
PP1R7_HUMAN Regulatory subunit of protein phosphatase 1.
Publication Abstract from PubMed
Protein phosphatase 1 (PP1) dephosphorylates hundreds of key biological targets by associating with nearly 200 regulatory proteins to form highly specific holoenzymes. The vast majority of regulators are intrinsically disordered proteins (IDPs) and bind PP1 via short linear motifs within their intrinsically disordered regions. One of the most ancient PP1 regulators is SDS22, a protein that is conserved from yeast to mammals. Sequence analysis of SDS22 revealed that it is a leucine-rich repeat (LRR) protein, suggesting that SDS22, unlike nearly every other known PP1 regulator, is not an IDP but instead is fully structured. Here, the 2.9 A resolution crystal structure of human SDS22 in space group P212121 is reported. SDS22 adopts an LRR fold with the horseshoe-like curvature typical for this family of proteins. The structure results in surfaces with distinct chemical characteristics that are likely to be critical for PP1 binding.
The structure of SDS22 provides insights into the mechanism of heterodimer formation with PP1.,Choy MS, Bolik-Coulon N, Archuleta TL, Peti W, Page R Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):817-824. doi:, 10.1107/S2053230X18016503. Epub 2018 Nov 30. PMID:30511677[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Choy MS, Bolik-Coulon N, Archuleta TL, Peti W, Page R. The structure of SDS22 provides insights into the mechanism of heterodimer formation with PP1. Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):817-824. doi:, 10.1107/S2053230X18016503. Epub 2018 Nov 30. PMID:30511677 doi:http://dx.doi.org/10.1107/S2053230X18016503
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