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6mo2

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Current revision (06:35, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6mo2' size='340' side='right'caption='[[6mo2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='6mo2' size='340' side='right'caption='[[6mo2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mo2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MO2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MO2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JVM:1-(4-{5-[(piperidin-4-yl)methoxy]-3-[4-(1H-pyrazol-4-yl)phenyl]pyrazin-2-yl}phenyl)methanamine'>JVM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mo2 OCA], [http://pdbe.org/6mo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mo2 RCSB], [http://www.ebi.ac.uk/pdbsum/6mo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mo2 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JVM:1-(4-{5-[(piperidin-4-yl)methoxy]-3-[4-(1H-pyrazol-4-yl)phenyl]pyrazin-2-yl}phenyl)methanamine'>JVM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mo2 OCA], [https://pdbe.org/6mo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mo2 RCSB], [https://www.ebi.ac.uk/pdbsum/6mo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mo2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0B4L2Y4_9FLAV A0A0B4L2Y4_9FLAV] [https://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6mo2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6mo2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hua, Y]]
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[[Category: Hua Y]]
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[[Category: Huo, T]]
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[[Category: Huo T]]
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[[Category: Lin, Y L]]
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[[Category: Lin Y-L]]
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[[Category: Nie, S]]
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[[Category: Nie S]]
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[[Category: Song, Y]]
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[[Category: Song Y]]
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[[Category: Wu, F]]
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[[Category: Wu F]]
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[[Category: Wu, J]]
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[[Category: Wu J]]
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[[Category: Yao, Y]]
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[[Category: Yao Y]]
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[[Category: Allosteric inhibitor]]
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[[Category: Complex]]
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[[Category: Inhibitor]]
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[[Category: Protease]]
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[[Category: Viral protein]]
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[[Category: Viral protein-inhibitor complex]]
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Current revision

Structure of dengue virus protease with an allosteric Inhibitor that blocks replication

PDB ID 6mo2

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OCA

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