6n48

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Current revision (06:44, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6n48' size='340' side='right'caption='[[6n48]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6n48' size='340' side='right'caption='[[6n48]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6n48]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelidae Camelidae] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N48 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6n48]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae Camelidae], [https://en.wikipedia.org/wiki/Enterobacteria_phage_RB59 Enterobacteria phage RB59] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N48 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=KBY:N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine'>KBY</scene>, <scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=KBY:N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine'>KBY</scene>, <scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n48 OCA], [https://pdbe.org/6n48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n48 RCSB], [https://www.ebi.ac.uk/pdbsum/6n48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n48 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n48 OCA], [http://pdbe.org/6n48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n48 RCSB], [http://www.ebi.ac.uk/pdbsum/6n48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n48 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6n48" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6n48" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
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*[[Antibody 3D structures|Antibody 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Camelidae]]
[[Category: Camelidae]]
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[[Category: Human]]
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[[Category: Enterobacteria phage RB59]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lysozyme]]
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[[Category: Ahn S]]
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[[Category: Ahn, S]]
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[[Category: Hirata K]]
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[[Category: Hirata, K]]
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[[Category: Huang LY]]
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[[Category: Huang, L Y]]
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[[Category: Kahsai AW]]
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[[Category: Kahsai, A W]]
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[[Category: Kobilka BK]]
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[[Category: Kobilka, B K]]
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[[Category: Lefkowitz RJ]]
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[[Category: Lefkowitz, R J]]
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[[Category: Liu X]]
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[[Category: Liu, X]]
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[[Category: Masoudi A]]
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[[Category: Masoudi, A]]
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[[Category: Pani B]]
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[[Category: Pani, B]]
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[[Category: G protein coupled receptor]]
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[[Category: Membrane protein]]
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[[Category: Signaling protein]]
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Current revision

Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator

PDB ID 6n48

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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