1ndn

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[[Image:1ndn.jpg|left|200px]]
[[Image:1ndn.jpg|left|200px]]
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{{Structure
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|PDB= 1ndn |SIZE=350|CAPTION= <scene name='initialview01'>1ndn</scene>, resolution 3.000&Aring;
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The line below this paragraph, containing "STRUCTURE_1ndn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1ndn| PDB=1ndn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ndn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ndn OCA], [http://www.ebi.ac.uk/pdbsum/1ndn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ndn RCSB]</span>
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'''MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4'''
'''MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4'''
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==About this Structure==
==About this Structure==
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1NDN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDN OCA].
==Reference==
==Reference==
Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2320572 2320572]
Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2320572 2320572]
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[[Category: Protein complex]]
 
[[Category: Aymani, J.]]
[[Category: Aymani, J.]]
[[Category: Boom, J H.Van.]]
[[Category: Boom, J H.Van.]]
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[[Category: Rich, A.]]
[[Category: Rich, A.]]
[[Category: Wang, A H.J.]]
[[Category: Wang, A H.J.]]
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[[Category: b-dna]]
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[[Category: B-dna]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: nicked]]
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[[Category: Nicked]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:24:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:28:58 2008''
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Revision as of 23:24, 2 May 2008

Image:1ndn.jpg

Template:STRUCTURE 1ndn

MOLECULAR STRUCTURE OF NICKED DNA. MODEL T4


Overview

The molecular structure of a nicked dodecamer DNA double helix, made of a ternary system containing d(CGCGAAAACGCG) + d(CGCGTT) + d(TTCGCG) oligonucleotides, has been determined by x-ray diffraction analysis at 3 A resolution. The molecule adopts a B-DNA conformation, not unlike those found in intact dodecamer DNA molecules crystallized in a somewhat different crystal lattice, despite a gap due to the absence of a phosphate group in the molecule. The helix has a distinct narrow minor groove near the center of the molecule at the AAAA region. This suggests that the internal stabilizing forces due to base stacking and hydrogen-bonding interactions are sufficient to overcome the loss of connectivity associated with the disruption of the covalent backbone of DNA.

About this Structure

Full crystallographic information is available from OCA.

Reference

Molecular structure of nicked DNA: a substrate for DNA repair enzymes., Aymami J, Coll M, van der Marel GA, van Boom JH, Wang AH, Rich A, Proc Natl Acad Sci U S A. 1990 Apr;87(7):2526-30. PMID:2320572 Page seeded by OCA on Sat May 3 02:24:31 2008

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