6nda

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Current revision (06:50, 11 October 2023) (edit) (undo)
 
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==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM==
==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM==
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<StructureSection load='6nda' size='340' side='right' caption='[[6nda]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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<StructureSection load='6nda' size='340' side='right'caption='[[6nda]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6nda]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NDA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6nda]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NDA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nda OCA], [http://pdbe.org/6nda PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nda RCSB], [http://www.ebi.ac.uk/pdbsum/6nda PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nda ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nda OCA], [https://pdbe.org/6nda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nda RCSB], [https://www.ebi.ac.uk/pdbsum/6nda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nda ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref> [[http://www.uniprot.org/uniprot/ITA2_HUMAN ITA2_HUMAN]] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. [[http://www.uniprot.org/uniprot/SLED_CALRH SLED_CALRH]] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>
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[https://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>
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==See Also==
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*[[Integrin 3D structures|Integrin 3D structures]]
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*[[Rhodocetin|Rhodocetin]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Calloselasma rhodostoma]]
[[Category: Calloselasma rhodostoma]]
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[[Category: Loewen, P C]]
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[[Category: Homo sapiens]]
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[[Category: McDougall, M D]]
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[[Category: Large Structures]]
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[[Category: Stetefeld, J]]
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[[Category: Loewen PC]]
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[[Category: C-type lectin]]
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[[Category: McDougall MD]]
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[[Category: Cadmium]]
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[[Category: Stetefeld J]]
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[[Category: Cell adhesion]]
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[[Category: Cell adhesion-toxin complex]]
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[[Category: Coagulation]]
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[[Category: Integrin]]
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[[Category: Venom]]
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Current revision

RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND CADMIUM

PDB ID 6nda

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