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6now

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Current revision (06:57, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6now]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6NOW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6now]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NOW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AARS2, AARSL, KIAA1270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.099&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [https://pdbe.org/6now PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [https://www.ebi.ac.uk/pdbsum/6now PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [http://pdbe.org/6now PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [http://www.ebi.ac.uk/pdbsum/6now PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Combined oxidative phosphorylation defect type 8;Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN] Combined oxidative phosphorylation defect type 8;Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]
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[https://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6now" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6now" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alanine--tRNA ligase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kuhle, B]]
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[[Category: Kuhle B]]
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[[Category: Schimmel, P]]
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[[Category: Schimmel P]]
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[[Category: Alanyl-trna synthetase]]
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[[Category: Alpha-beta domain]]
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[[Category: C-terminal domain]]
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[[Category: Ligase]]
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[[Category: Mitochondria]]
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Current revision

Human Mitochondrial Alanyl-tRNA Synthetase C-Ala domain

PDB ID 6now

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OCA

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