6oda
From Proteopedia
(Difference between revisions)
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<StructureSection load='6oda' size='340' side='right'caption='[[6oda]], [[Resolution|resolution]] 2.88Å' scene=''> | <StructureSection load='6oda' size='340' side='right'caption='[[6oda]], [[Resolution|resolution]] 2.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6oda]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODA OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6oda]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ODA FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C7:2-(4-CHLOROPHENYL)-4-[(3S)-PIPERIDIN-3-YLAMINO]THIENO[2,3-D]PYRIDAZINE-7-CARBOXAMIDE'>C7</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C7:2-(4-CHLOROPHENYL)-4-[(3S)-PIPERIDIN-3-YLAMINO]THIENO[2,3-D]PYRIDAZINE-7-CARBOXAMIDE'>C7</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oda OCA], [https://pdbe.org/6oda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oda RCSB], [https://www.ebi.ac.uk/pdbsum/6oda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oda ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bair | + | [[Category: Bair K]] |
| - | [[Category: Barczak | + | [[Category: Barczak N]] |
| - | [[Category: Caravella | + | [[Category: Caravella J]] |
| - | [[Category: Conti | + | [[Category: Conti C]] |
| - | [[Category: Garcia-Dancey | + | [[Category: Garcia-Dancey R]] |
| - | [[Category: Han | + | [[Category: Han B]] |
| - | [[Category: Hardy | + | [[Category: Hardy C]] |
| - | [[Category: Lahdenranta | + | [[Category: Lahdenranta J]] |
| - | [[Category: Lancia | + | [[Category: Lancia Jr D]] |
| - | [[Category: Leng | + | [[Category: Leng C]] |
| - | [[Category: Li | + | [[Category: Li P]] |
| - | [[Category: Liu | + | [[Category: Liu C]] |
| - | [[Category: Martin | + | [[Category: Martin M]] |
| - | [[Category: Ng | + | [[Category: Ng PY]] |
| - | [[Category: Pardo | + | [[Category: Pardo E]] |
| - | [[Category: Rudnitskaya | + | [[Category: Rudnitskaya A]] |
| - | [[Category: Saldahna | + | [[Category: Saldahna A]] |
| - | [[Category: Tan | + | [[Category: Tan T]] |
| - | [[Category: Thomason | + | [[Category: Thomason JJ]] |
| - | [[Category: Toms | + | [[Category: Toms AV]] |
| - | [[Category: Yao | + | [[Category: Yao L]] |
| - | [[Category: Zablocki | + | [[Category: Zablocki M-M]] |
| - | [[Category: Zhang | + | [[Category: Zhang C]] |
| - | [[Category: Zheng | + | [[Category: Zheng X]] |
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Current revision
Crystal structure of HDAC8 in complex with compound 2
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Categories: Homo sapiens | Large Structures | Bair K | Barczak N | Caravella J | Conti C | Garcia-Dancey R | Han B | Hardy C | Lahdenranta J | Lancia Jr D | Leng C | Li P | Liu C | Martin M | Ng PY | Pardo E | Rudnitskaya A | Saldahna A | Tan T | Thomason JJ | Toms AV | Yao L | Zablocki M-M | Zhang C | Zheng X
