6oxb

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Current revision (07:18, 11 October 2023) (edit) (undo)
 
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==First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1)==
==First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1)==
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<StructureSection load='6oxb' size='340' side='right'caption='[[6oxb]]' scene=''>
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<StructureSection load='6oxb' size='340' side='right'caption='[[6oxb]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OXB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OXB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6oxb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OXB FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6oxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oxb OCA], [http://pdbe.org/6oxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oxb RCSB], [http://www.ebi.ac.uk/pdbsum/6oxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oxb ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oxb OCA], [https://pdbe.org/6oxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oxb RCSB], [https://www.ebi.ac.uk/pdbsum/6oxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oxb ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cochran AG]]
[[Category: Cochran AG]]

Current revision

First bromo-adjacent homology (BAH) domain of human Polybromo-1 (PBRM1)

PDB ID 6oxb

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