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6pcu

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Current revision (07:27, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6pcu' size='340' side='right'caption='[[6pcu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6pcu' size='340' side='right'caption='[[6pcu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pcu]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Group_a_rotaviruses Group a rotaviruses] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PCU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pcu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rotavirus_A Rotavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PCU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pcu OCA], [http://pdbe.org/6pcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pcu RCSB], [http://www.ebi.ac.uk/pdbsum/6pcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pcu ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pcu OCA], [https://pdbe.org/6pcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pcu RCSB], [https://www.ebi.ac.uk/pdbsum/6pcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pcu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q2VE61_9REOV Q2VE61_9REOV]] Outer capsid protein VP5*: Forms the spike "foot" and "body" and acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. During entry, the part of VP5* that protrudes from the virus folds back on itself and reorganizes from a local dimer to a trimer. This reorganization may be linked to membrane penetration by exposing VP5* hydrophobic region. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS01043052]
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[https://www.uniprot.org/uniprot/Q2VE61_9VIRU Q2VE61_9VIRU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6pcu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6pcu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Group a rotaviruses]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hu, L]]
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[[Category: Rotavirus A]]
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[[Category: Prasad, B V.Venkataram]]
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[[Category: Hu L]]
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[[Category: Antibody]]
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[[Category: Venkataram Prasad BV]]
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[[Category: Rotavirus]]
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[[Category: Scfv]]
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[[Category: Viral protein]]
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[[Category: Viral protein-immune system complex]]
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Current revision

VP8* of a G2P[4] human rotavirus in complex with scFv antibody 9

PDB ID 6pcu

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