6pjj

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<StructureSection load='6pjj' size='340' side='right'caption='[[6pjj]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6pjj' size='340' side='right'caption='[[6pjj]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pjj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PJJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pjj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PJJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OCJ:4-(5-{[(3-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide'>OCJ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OCJ:4-(5-{[(3-aminophenyl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide'>OCJ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pjj OCA], [https://pdbe.org/6pjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pjj RCSB], [https://www.ebi.ac.uk/pdbsum/6pjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pjj ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pjj OCA], [http://pdbe.org/6pjj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pjj RCSB], [http://www.ebi.ac.uk/pdbsum/6pjj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pjj ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN]] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
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[https://www.uniprot.org/uniprot/PRP4B_HUMAN PRP4B_HUMAN] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Arruda P]]
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[[Category: Arruda, P]]
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[[Category: Azevedo H]]
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[[Category: Azevedo, H]]
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[[Category: Counago RM]]
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[[Category: Counago, R M]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M]]
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[[Category: Fala AM]]
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[[Category: Fala, A M]]
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[[Category: Godoi PHC]]
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[[Category: Godoi, P H.C]]
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[[Category: Guimaraes CRW]]
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[[Category: Guimaraes, C R.W]]
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[[Category: Mascarello A]]
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[[Category: Mascarello, A]]
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[[Category: Ramos PZ]]
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[[Category: Ramos, P Z]]
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[[Category: Santiago AS]]
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[[Category: Structural genomic]]
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[[Category: Segretti N]]
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[[Category: Santiago, A S]]
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[[Category: Sriranganadane D]]
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[[Category: Segretti, N]]
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[[Category: Sriranganadane, D]]
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[[Category: Serine/threonine-protein kinase prp4 homolog]]
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[[Category: Sgc]]
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[[Category: Splicing kinase prpf4b]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 07:30, 11 October 2023

Human PRPF4B bound to benzothiophene inhibitor 224

PDB ID 6pjj

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