6pz2

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Current revision (07:38, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6pz2' size='340' side='right'caption='[[6pz2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='6pz2' size='340' side='right'caption='[[6pz2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pz2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_difficilis"_hall_and_o'toole_1935 "bacillus difficilis" hall and o'toole 1935]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PZ2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PZ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=PT1:PTEROIC+ACID'>PT1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folP, SAMEA3374989_02220 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 "Bacillus difficilis" Hall and O'Toole 1935])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=PT1:PTEROIC+ACID'>PT1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pz2 OCA], [https://pdbe.org/6pz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pz2 RCSB], [https://www.ebi.ac.uk/pdbsum/6pz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pz2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pz2 OCA], [http://pdbe.org/6pz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pz2 RCSB], [http://www.ebi.ac.uk/pdbsum/6pz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pz2 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/A0A160WS51_CLODI A0A160WS51_CLODI]] Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.[RuleBase:RU361205]
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==See Also==
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*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus difficilis hall and o'toole 1935]]
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[[Category: Clostridioides difficile]]
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[[Category: Dihydropteroate synthase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Girardi, N M]]
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[[Category: Girardi NM]]
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[[Category: Holden, H M]]
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[[Category: Holden HM]]
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[[Category: Thoden, J B]]
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[[Category: Thoden JB]]
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[[Category: Antibiotic resistance]]
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[[Category: Clostridium]]
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[[Category: Dhp]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of FolP (dihydropteroate synthase) from Colstridium difficile in the presence of pteroic acid

PDB ID 6pz2

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