1nzq

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(New page: 200px<br /> <applet load="1nzq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nzq, resolution 2.18&Aring;" /> '''D-Phe-Pro-Arg-Type ...)
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Revision as of 16:21, 12 November 2007

Image:1nzq.gif

1nzq, resolution 2.18Å

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D-Phe-Pro-Arg-Type Thrombin Inhibitor

Contents

Overview

Synthesis of thrombin inhibitors and their binding mode to thrombin is, described. Modification of the P1 moiety leads to an increased selectivity, versus trypsin. The observed selectivity is discussed in view of their, thrombin-inhibitor complex X-ray structures.

Disease

Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1NZQ is a Protein complex structure of sequences from Homo sapiens with 162 as ligand. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.

Reference

D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189

Page seeded by OCA on Mon Nov 12 18:27:26 2007

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