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6u4p

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Current revision (07:43, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6u4p' size='340' side='right'caption='[[6u4p]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
<StructureSection load='6u4p' size='340' side='right'caption='[[6u4p]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6u4p]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U4P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U4P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6u4p]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U4P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PQJ:fos-choline-14'>PQJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6u3t|6u3t]], [[6u49|6u49]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PQJ:fos-choline-14'>PQJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hly, hla ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u4p OCA], [https://pdbe.org/6u4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u4p RCSB], [https://www.ebi.ac.uk/pdbsum/6u4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u4p ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u4p OCA], [http://pdbe.org/6u4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u4p RCSB], [http://www.ebi.ac.uk/pdbsum/6u4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u4p ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU]] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
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[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6u4p" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6u4p" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Hemolysin 3D structures|Hemolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kozhaya, L]]
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[[Category: Staphylococcus aureus]]
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[[Category: Liu, J]]
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[[Category: Kozhaya L]]
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[[Category: Lu, M]]
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[[Category: Liu J]]
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[[Category: Torres, V J]]
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[[Category: Lu M]]
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[[Category: Unutmaz, D]]
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[[Category: Torres VJ]]
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[[Category: Alpha-toxin]]
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[[Category: Unutmaz D]]
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[[Category: Leukocidin]]
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[[Category: Mrsa]]
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[[Category: Pvl]]
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[[Category: Toxin]]
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Current revision

Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus

PDB ID 6u4p

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