6uyn

==Crystal structure of influenza A virus hemagglutinin from A/Ohio/09/2015 bound to the stalk-binding CR6261 antibody Fab==

<StructureSection load='6uyn' size='340' side='right'caption='[[6uyn]], [[Resolution|resolution]] 2.85&Aring;' scene=''>

<table><tr><td colspan='2'>[[6uyn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UYN FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uyn OCA], [https://pdbe.org/6uyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uyn RCSB], [https://www.ebi.ac.uk/pdbsum/6uyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uyn ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/A0A6C0TB04_9INFA A0A6C0TB04_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]

==See Also==

*[[Antibody 3D structures|Antibody 3D structures]]

*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]

[[Category: Homo sapiens]]

[[Category: Influenza A virus]]

[[Category: Structural genomic]]