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6v3c

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Current revision (08:03, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6v3c' size='340' side='right'caption='[[6v3c]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
<StructureSection load='6v3c' size='340' side='right'caption='[[6v3c]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6v3c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V3C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v3c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V3C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LNK:PENTANE'>LNK</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=RU3:ruthenium(6+)+formate+azanide+tetraamino(formato-kappaO)oxidoruthenate(1-)+(1/1/4/1)'>RU3</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.51&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3c OCA], [http://pdbe.org/6v3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v3c RCSB], [http://www.ebi.ac.uk/pdbsum/6v3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3c ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LNK:PENTANE'>LNK</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=RU3:ruthenium(6+)+formate+azanide+tetraamino(formato-kappaO)oxidoruthenate(1-)+(1/1/4/1)'>RU3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3c OCA], [https://pdbe.org/6v3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v3c RCSB], [https://www.ebi.ac.uk/pdbsum/6v3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3c ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCNK2_MOUSE KCNK2_MOUSE] Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152).<ref>PMID:10321245</ref> <ref>PMID:16636285</ref> <ref>PMID:24496152</ref> <ref>PMID:9003761</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6v3c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6v3c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lolicato, M]]
 
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[[Category: Minor, D L]]
 
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[[Category: Pope, L]]
 
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[[Category: K channel]]
 
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[[Category: Membrane protein]]
 
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Trek-1]]
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[[Category: Lolicato M]]
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[[Category: Minor DL]]
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[[Category: Pope L]]

Current revision

K2P2.1(TREK-1)I110D:Ru360 bound channel structure

PDB ID 6v3c

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