6v8d

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Current revision (08:05, 11 October 2023) (edit) (undo)
 
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==Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators==
==Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators==
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<StructureSection load='6v8d' size='340' side='right'caption='[[6v8d]]' scene=''>
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<StructureSection load='6v8d' size='340' side='right'caption='[[6v8d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V8D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v8d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V8D FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8d OCA], [http://pdbe.org/6v8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v8d RCSB], [http://www.ebi.ac.uk/pdbsum/6v8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8d ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O78:(3Z)-3-iminocyclohex-1-ene-1-carboxylic+acid'>O78</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8d OCA], [https://pdbe.org/6v8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v8d RCSB], [https://www.ebi.ac.uk/pdbsum/6v8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8d ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN] Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:[https://omim.org/entry/258870 258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.<ref>PMID:3375240</ref> <ref>PMID:2793865</ref> <ref>PMID:1612597</ref> <ref>PMID:1737786</ref> <ref>PMID:7887415</ref> <ref>PMID:7668253</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/OAT_HUMAN OAT_HUMAN]
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==See Also==
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*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Butrin A]]
[[Category: Butrin A]]

Current revision

Design, Synthesis, and Mechanism of Fluorine-substituted Cyclohexene Analogues of GAMA-Aminobutyric Acid (GABA) as Selective Ornithine Aminotransferase Inactivators

PDB ID 6v8d

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