6va5

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Current revision (08:07, 11 October 2023) (edit) (undo)
 
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==Tudor Domain of Tumor suppressor p53BP1 with MFP-4184==
==Tudor Domain of Tumor suppressor p53BP1 with MFP-4184==
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<StructureSection load='6va5' size='340' side='right'caption='[[6va5]]' scene=''>
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<StructureSection load='6va5' size='340' side='right'caption='[[6va5]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VA5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VA5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6va5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VA5 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6va5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6va5 OCA], [http://pdbe.org/6va5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6va5 RCSB], [http://www.ebi.ac.uk/pdbsum/6va5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6va5 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QSS:2-(4-methylpiperazin-1-yl)aniline'>QSS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6va5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6va5 OCA], [https://pdbe.org/6va5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6va5 RCSB], [https://www.ebi.ac.uk/pdbsum/6va5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6va5 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
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== Function ==
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith CH]]

Current revision

Tudor Domain of Tumor suppressor p53BP1 with MFP-4184

PDB ID 6va5

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