6vbi
From Proteopedia
(Difference between revisions)
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==crystal structure of PDE5 in complex with a non-competitive inhibitor== | ==crystal structure of PDE5 in complex with a non-competitive inhibitor== | ||
| - | <StructureSection load='6vbi' size='340' side='right'caption='[[6vbi]]' scene=''> | + | <StructureSection load='6vbi' size='340' side='right'caption='[[6vbi]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VBI OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6vbi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VBI FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3000076Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FZA:(13bS)-4,9-dimethoxy-14-methyl-8,13,13b,14-tetrahydroindolo[2,3 3,4]pyrido[2,1-b]quinazolin-5(7H)-one'>FZA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vbi OCA], [https://pdbe.org/6vbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vbi RCSB], [https://www.ebi.ac.uk/pdbsum/6vbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vbi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ke H]] | [[Category: Ke H]] | ||
[[Category: Luo HB]] | [[Category: Luo HB]] | ||
Revision as of 08:08, 11 October 2023
crystal structure of PDE5 in complex with a non-competitive inhibitor
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