6vd9
From Proteopedia
(Difference between revisions)
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==Metal-bound C-terminal domain of the CzcD transporter from Cuprividus metallidurans== | ==Metal-bound C-terminal domain of the CzcD transporter from Cuprividus metallidurans== | ||
| - | <StructureSection load='6vd9' size='340' side='right'caption='[[6vd9]]' scene=''> | + | <StructureSection load='6vd9' size='340' side='right'caption='[[6vd9]], [[Resolution|resolution]] 1.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VD9 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6vd9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_metallidurans_CH34 Cupriavidus metallidurans CH34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VD9 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vd9 OCA], [https://pdbe.org/6vd9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vd9 RCSB], [https://www.ebi.ac.uk/pdbsum/6vd9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vd9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CZCD_CUPMC CZCD_CUPMC] Mediates a low-level metal ion resistance, probably by efflux of cations from the cytoplasm into the periplasm. Also mediates resistance to cobalt, cadmium and zinc via regulation of the Czc system. May repress expression of the Czc system by an export of the inducing cations. Binds and transports zinc. Can also bind cobalt, copper and nickel.<ref>PMID:10559151</ref> <ref>PMID:15516561</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Zinc is a potent antimicrobial component of the innate immune response at the host-pathogen interface. Bacteria subvert or resist host zinc insults by metal efflux pathways that include cation diffusion facilitator (CDF) proteins. The structural and functional examination of this protein class has been limited, with only the structures of the zinc transporter YiiP proteins from E. coli and Shewanella oneidensis described to date. Here, we determine the metal binding properties, solution quaternary structures and three dimensional architectures of the C-terminal domains of the metal transporter CzcD proteins from Cupriavidus metallidurans, Pseudomonas aeruginosa and Thermotoga maritima. We reveal significant diversity in the metal-binding properties and structures of these proteins and discover a potential novel mechanism for metal-promoted dimerization for the Cupriavidus metallidurans and Pseudomonas aeruginosa proteins. | ||
| + | |||
| + | Structural and functional characterizations of the C-terminal domains of CzcD proteins.,Udagedara SR, La Porta DM, Spehar C, Purohit G, Hein MJA, Fatmous ME, Casas Garcia GP, Ganio K, McDevitt CA, Maher MJ J Inorg Biochem. 2020 Jul;208:111087. doi: 10.1016/j.jinorgbio.2020.111087. Epub , 2020 Apr 23. PMID:32505855<ref>PMID:32505855</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6vd9" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Cupriavidus metallidurans CH34]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Maher MJ]] | [[Category: Maher MJ]] | ||
Current revision
Metal-bound C-terminal domain of the CzcD transporter from Cuprividus metallidurans
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