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6via

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Current revision (08:13, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6via' size='340' side='right'caption='[[6via]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='6via' size='340' side='right'caption='[[6via]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6via]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupmc Cupmc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VIA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6via]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupriavidus_metallidurans_CH34 Cupriavidus metallidurans CH34]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VIA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EAY:(2R,3E)-2-hydroxy-3-imino-2,3-dihydrooxepine-4-carboxylic+acid'>EAY</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.591&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nbaC, Rmet_5193 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EAY:(2R,3E)-2-hydroxy-3-imino-2,3-dihydrooxepine-4-carboxylic+acid'>EAY</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6via OCA], [https://pdbe.org/6via PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6via RCSB], [https://www.ebi.ac.uk/pdbsum/6via PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6via ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6via OCA], [https://pdbe.org/6via PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6via RCSB], [https://www.ebi.ac.uk/pdbsum/6via PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6via ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/3HAO_CUPMC 3HAO_CUPMC]] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.[HAMAP-Rule:MF_00825]<ref>PMID:15909977</ref>
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[https://www.uniprot.org/uniprot/3HAO_CUPMC 3HAO_CUPMC] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.[HAMAP-Rule:MF_00825]<ref>PMID:15909977</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-hydroxyanthranilate 3,4-dioxygenase]]
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[[Category: Cupriavidus metallidurans CH34]]
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[[Category: Cupmc]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Liu, A]]
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[[Category: Liu A]]
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[[Category: Liu, F]]
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[[Category: Liu F]]
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[[Category: Wang, Y]]
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[[Category: Wang Y]]
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[[Category: Yang, Y]]
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[[Category: Yang Y]]
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[[Category: Extradiol dioxygenase]]
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[[Category: In crystallo reaction]]
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[[Category: Intermediate]]
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[[Category: Nad+ biosynthesis]]
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[[Category: Oxidoreductase]]
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Current revision

Observing a ring-cleaving dioxygenase in action through a crystalline lens - a seven-membered lactone bound structure

PDB ID 6via

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OCA

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