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6vif

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Current revision (08:13, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6vif' size='340' side='right'caption='[[6vif]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
<StructureSection load='6vif' size='340' side='right'caption='[[6vif]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6vif]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VIF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6vif]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VIF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QY4:N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl)amino]methyl}-1,6 7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric+diamide'>QY4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR5A2, B1F, CPF, FTF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QY4:N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl)amino]methyl}-1,6 7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric+diamide'>QY4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vif OCA], [http://pdbe.org/6vif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vif RCSB], [http://www.ebi.ac.uk/pdbsum/6vif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vif ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vif OCA], [https://pdbe.org/6vif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vif RCSB], [https://www.ebi.ac.uk/pdbsum/6vif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vif ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6vif" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6vif" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Liver receptor homolog-1|Liver receptor homolog-1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cato, M L]]
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[[Category: Cato ML]]
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[[Category: Ortlund, E A]]
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[[Category: Ortlund EA]]
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[[Category: Agonist]]
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[[Category: Ligand-binding domain]]
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[[Category: Liver receptor homolog-1]]
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[[Category: Nuclear protein]]
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[[Category: Nuclear receptor]]
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[[Category: Small molecule]]
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Current revision

Human LRH-1 ligand-binding domain bound to agonist cpd 15 and fragment of coregulator TIF-2

PDB ID 6vif

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