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5lc0

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Current revision (08:55, 11 October 2023) (edit) (undo)
 
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<StructureSection load='5lc0' size='340' side='right'caption='[[5lc0]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5lc0' size='340' side='right'caption='[[5lc0]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Zikv Zikv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LC0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LC0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LC0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6T8:N-((S)-3-(4-(AMINOMETHYL)PHENYL)-1-(((R)-4-GUANIDINO-1-(5-HYDROXY-1,3,2-DIOXABORINAN-2-YL)BUTYL)AMINO)-1-OXOPROPAN-2-YL)BENZAMIDE'>6T8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lc0 OCA], [http://pdbe.org/5lc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5lc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lc0 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6T8:N-((S)-3-(4-(AMINOMETHYL)PHENYL)-1-(((R)-4-GUANIDINO-1-(5-HYDROXY-1,3,2-DIOXABORINAN-2-YL)BUTYL)AMINO)-1-OXOPROPAN-2-YL)BENZAMIDE'>6T8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lc0 OCA], [https://pdbe.org/5lc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lc0 RCSB], [https://www.ebi.ac.uk/pdbsum/5lc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lc0 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A140DLX4_ZIKV A0A140DLX4_ZIKV] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5lc0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lc0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Zikv]]
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[[Category: Zika virus]]
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[[Category: Hansen, G]]
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[[Category: Hansen G]]
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[[Category: Hilgenfeld, R]]
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[[Category: Hilgenfeld R]]
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[[Category: Lei, J]]
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[[Category: Lei J]]
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[[Category: Zhang, L L]]
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[[Category: Zhang LL]]
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[[Category: Antiviral agent]]
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[[Category: Boronic-acid inhibitor]]
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[[Category: Cyclic diester with glycerol]]
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[[Category: Hydrolase]]
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[[Category: Zika virus ns2b-ns3 protease]]
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Current revision

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

PDB ID 5lc0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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