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5lc8

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Current revision (08:55, 11 October 2023) (edit) (undo)
 
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<StructureSection load='5lc8' size='340' side='right'caption='[[5lc8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5lc8' size='340' side='right'caption='[[5lc8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LC8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LC8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LC8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZPE:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADEC-5-ENOYLOXY)PROPYL+(11Z)-OCTADEC-11-ENOATE'>ZPE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMPREF1223_10352 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZPE:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADEC-5-ENOYLOXY)PROPYL+(11Z)-OCTADEC-11-ENOATE'>ZPE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lc8 OCA], [http://pdbe.org/5lc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lc8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lc8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lc8 OCA], [https://pdbe.org/5lc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lc8 RCSB], [https://www.ebi.ac.uk/pdbsum/5lc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lc8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LOX_PSEAI LOX_PSEAI] In presence of oxygen, converts oleic acid into (S)-(E)-10-hydroperoxy-8-octadecenoic acid (HPOD), which spontaneously decomposes to the corresponding (E)-10-hydroxy-8-octadecenoic acid (HOD). In vivo, the reaction leads to the dihydroxy derivative (E)-7,10-dihydroxy-8-octadecenoic acid (DHOD), so that the three hydroxy-fatty acids can be isolated from the culture medium. Also active on linoleic acid and linolenic acid. Almost not active on arachidonic acid.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Banthiya, S]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Kalms, J]]
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[[Category: Banthiya S]]
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[[Category: Kuhn, H]]
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[[Category: Galemou Yoga E]]
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[[Category: Scheerer, P]]
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[[Category: Kalms J]]
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[[Category: Yoga, E Galemou]]
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[[Category: Kuhn H]]
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[[Category: A420g mutant]]
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[[Category: Scheerer P]]
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[[Category: Arachidonate 15s-lipoxygenase]]
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[[Category: Eicosanoid]]
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[[Category: Infectious disease]]
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[[Category: Linoleate 13s-lipoxygenase]]
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[[Category: Non-heme iron enzyme]]
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[[Category: Oxidoreductase]]
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[[Category: Protein-phospholipid complex]]
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Current revision

Crystal Structure of specific mutant from Pseudomonas aeruginosa Lipoxygenase at 1.8A resolution

PDB ID 5lc8

Drag the structure with the mouse to rotate

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OCA

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