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Rho guanine nucleotide exchange factor 3D structures

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**[[3p6a]] – hGEF DH/PH domain (mutant)<br />
**[[3p6a]] – hGEF DH/PH domain (mutant)<br />
**[[1shz]], [[3ab3]] – hGEF N terminal RGS domain + guanine nucleotide-binding protein<br />
**[[1shz]], [[3ab3]] – hGEF N terminal RGS domain + guanine nucleotide-binding protein<br />
 +
 +
*GEF guanine nucleotide exchange factor 2
 +
 +
**[[8bnt]] – hGEF-H1 DH domain 206-448 + RhoA <br />
 +
**[[7g80]], [[7g81]], [[7g82]], [[7g83]], [[7g84]], [[7g85]], [[7g86]], [[7g88]], [[7g89]], [[7g8a]], [[7g8b]], [[7g8c]], [[7g8d]], [[7g8e]], [[7g8f]], [[7g8g]], [[7g8h]], [[7g8i]], [[7g8j]], [[7g8k]], [[7g8l]], [[7g8m]], [[7g8n]], [[7g8o]], [[7g8p]], [[7g8q]], [[7g8r]], [[7g87]], [[7g8s]], [[7g8t]], [[7g8u]], [[7g8v]], [[7g8w]], [[7g8x]], [[7g8y]], [[7g8z]], [[7g90]], [[7g91]], [[7g92]], [[7g93]], [[7g94]], [[7g95]], [[7g96]], [[7g97]], [[7g98]], [[7g99]], [[7g9a]], [[7g9b]], [[7g9c]], [[7g9d]], [[7g9e]], [[7g9f]], [[7g9g]], [[7g9h]], [[7g9i, [[7g9j]] – hGEF-H1 DH domain + RhoA + inhibitor<br />
 +
**[[5efx]] – hGEF-H1 439-582 <br />
*GEF guanine nucleotide exchange factor 3
*GEF guanine nucleotide exchange factor 3
Line 19: Line 25:
**[[2dx1]] – hGEF 59-540<br />
**[[2dx1]] – hGEF 59-540<br />
**[[2pz1]] – hGEF 137-599<br />
**[[2pz1]] – hGEF 137-599<br />
 +
**[[3nmx]], [[3nmz]] – hGEF 170-276 + APC<br />
*GEF guanine nucleotide exchange factor 6
*GEF guanine nucleotide exchange factor 6
Line 58: Line 65:
**[[2dls]] – hGEF PDZ domain 44-123 - NMR<br />
**[[2dls]] – hGEF PDZ domain 44-123 - NMR<br />
 +
**[[5e6p]] – hGEF PDZ domain + plexin-B2 <br />
**[[3kz1]], [[3t06]] – hGEF DH/PH domain 710-1085 + transforming protein GEFA <br />
**[[3kz1]], [[3t06]] – hGEF DH/PH domain 710-1085 + transforming protein GEFA <br />
 +
**[[5jhg]] – hGEF DH/PH domain + transforming protein RhoA <br />
 +
**[[5jhh]] – hGEF DH/PH domain + transforming protein RhoA + inhibitor<br />
**[[1xcg]] – hGEF DH/PH domain + transforming protein GEFA - NMR<br />
**[[1xcg]] – hGEF DH/PH domain + transforming protein GEFA - NMR<br />
-
**[[3cx6]] – rGEF RGS domain 307-508 + guanine nucleotide-binding protein <br />
+
**[[3cx6]], [[3cx8]] – rGEF RGS domain 307-508 + guanine nucleotide-binding protein <br />
*GEF guanine nucleotide exchange factor 12 (Leukemia-associated GEFGEF)
*GEF guanine nucleotide exchange factor 12 (Leukemia-associated GEFGEF)
Line 77: Line 87:
**[[6bcb]] – mGEF 302-444 + transforming protein RhoA<br />
**[[6bcb]] – mGEF 302-444 + transforming protein RhoA<br />
 +
 +
*GEF guanine nucleotide exchange factor 25
 +
 +
**[[2rgn]] – hGEF 149-502 + transforming protein RhoA + guanine nucleotide-binding protein G(I)<br />
*GEF guanine nucleotide exchange factor 28
*GEF guanine nucleotide exchange factor 28

Revision as of 10:08, 16 October 2023

3D Structures of Rho guanine nucleotide exchange factor

Updated on 16-October-2023 {{#tree:id=OrganizedByTopic|openlevels=0|

  • GEF guanine nucleotide exchange factor 1 (P115-GEFGEF)
    • 1iap – hGEF N terminal RGS domain 42-252 - human
    • 3odo, 3odw, 3odx – hGEF DH/PH domain 353-766
    • 3p6a – hGEF DH/PH domain (mutant)
    • 1shz, 3ab3 – hGEF N terminal RGS domain + guanine nucleotide-binding protein
  • GEF guanine nucleotide exchange factor 2
  • GEF guanine nucleotide exchange factor 3
    • 2z0q – mGEF DH/PH domain - mouse
  • GEF guanine nucleotide exchange factor 4 (Asef)
  • GEF guanine nucleotide exchange factor 6
    • 1ujy – hGEF SH3 domain 160-222 - NMR
    • 1wyr – hGEF CH domain 4-111 - NMR
  • GEF guanine nucleotide exchange factor 7 (b-PIX)
    • 1by1 – hGEF DH domain 81-289 - NMR
    • 2l3g – hGEF CH domain 1-137 - NMR
    • 2esw – mGEF SH3 domain 7-63
    • 2g6f – rGEF SH3 domain – rat
    • 2w6b – rGEF coiled-coil domain 588-638
  • GEF guanine nucleotide exchange factor 7 complex with peptide
    • 2ak5 – hGEF SH3 domain + CBL-b peptide
    • 2df6 – hGEF SH3 domain + PAK-1 peptide
    • 1zsg – hGEF residues 179-243 + PAK-1 peptide – NMR
    • 2p4r – rGEF SH3 domain + E3 ubiquitin protein ligase peptide
    • 3l4f – rGEF coiled-coil domain + SHANK1 PDZ domain
  • GEF guanine nucleotide exchange factor 8 (PRONE8)
    • 3eo2 – hGEF residues 161-373
    • 4xh9 – hGEF DH/PH domain + transforming protein GEFA
    • 2ntx – AtGEF PRONE domain 76-440 – Arabidopasis thaliana
    • 2wbl – AtGEF PRONE domain + GTPase ROP7
    • 2nty – AtGEF PRONE domain + GTPase ROP4 + GDP
  • GEF guanine nucleotide exchange factor 9 (collybistin)
    • 2ysq – hGEF SH3 domain - NMR
    • 4mt6, 4mt7 – rGEF (mutant)
    • 2dfk – rGEF II + CDC42
  • GEF guanine nucleotide exchange factor 11
    • 2dls – hGEF PDZ domain 44-123 - NMR
    • 5e6p – hGEF PDZ domain + plexin-B2
    • 3kz1, 3t06 – hGEF DH/PH domain 710-1085 + transforming protein GEFA
    • 5jhg – hGEF DH/PH domain + transforming protein RhoA
    • 5jhh – hGEF DH/PH domain + transforming protein RhoA + inhibitor
    • 1xcg – hGEF DH/PH domain + transforming protein GEFA - NMR
    • 3cx6, 3cx8 – rGEF RGS domain 307-508 + guanine nucleotide-binding protein
  • GEF guanine nucleotide exchange factor 12 (Leukemia-associated GEFGEF)
    • 1txd – hGEF DH/PH domain 764-1138
    • 2omj – hGEF PDZ domain 67-151
    • 1x86 – hGEF DH/PH domain (mutant) + transforming protein GEFA
    • 2os6 – hGEF PDZ domain + plexin peptide – NMR
  • GEF guanine nucleotide exchange factor 16 (Ephexin-4)
    • 1x6b – hGEF SH3 domain 334-399 - NMR
    • 7cso, 7csp, 7csr – mGEF 261-713 (mutant)
  • GEF guanine nucleotide exchange factor 18
    • 6bcb – mGEF 302-444 + transforming protein RhoA
  • GEF guanine nucleotide exchange factor 25
    • 2rgn – hGEF 149-502 + transforming protein RhoA + guanine nucleotide-binding protein G(I)
  • GEF guanine nucleotide exchange factor 28
    • 6bc1 – hGEF PH domain 1049-1194 + Ras-related C3 botulinum toxin substrate 1
    • 6bc0 – hGEF PH domain + transforming protein RhoA

}}

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Michal Harel

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