1nhc

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[[Image:1nhc.gif|left|200px]]
[[Image:1nhc.gif|left|200px]]
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{{Structure
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|PDB= 1nhc |SIZE=350|CAPTION= <scene name='initialview01'>1nhc</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1nhc", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polygalacturonase Polygalacturonase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.15 3.2.1.15] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1nhc| PDB=1nhc | SCENE= }}
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|RELATEDENTRY=[[1czf|1CZF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nhc OCA], [http://www.ebi.ac.uk/pdbsum/1nhc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nhc RCSB]</span>
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'''Structural insights into the processivity of endopolygalacturonase I from Aspergillus niger'''
'''Structural insights into the processivity of endopolygalacturonase I from Aspergillus niger'''
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[[Category: Pouderoyen, G van.]]
[[Category: Pouderoyen, G van.]]
[[Category: Snijder, H J.]]
[[Category: Snijder, H J.]]
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[[Category: beta-helix]]
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[[Category: Beta-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:31:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:30:22 2008''
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Revision as of 23:31, 2 May 2008

Image:1nhc.gif

Template:STRUCTURE 1nhc

Structural insights into the processivity of endopolygalacturonase I from Aspergillus niger


Overview

Endopolygalacturonase I is a processive enzyme, while the 60% sequence identical endopolygalacturonase II is not. The 1.70 A resolution crystal structure of endopolygalacturonase I reveals a narrowed substrate binding cleft. In addition, Arg96, a residue in this cleft previously shown to be critical for processivity, interacts with the substrate mimics glycerol and sulfate in several well-defined conformations in the six molecules in the asymmetric unit. From this we conclude that both Arg96 and the narrowed substrate binding cleft contribute to retaining the substrate while it moves through the active site after a cleavage event has occurred.

About this Structure

1NHC is a Single protein structure of sequence from Aspergillus niger. Full crystallographic information is available from OCA.

Reference

Structural insights into the processivity of endopolygalacturonase I from Aspergillus niger., van Pouderoyen G, Snijder HJ, Benen JA, Dijkstra BW, FEBS Lett. 2003 Nov 20;554(3):462-6. PMID:14623112 Page seeded by OCA on Sat May 3 02:31:59 2008

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