1ni1

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[[Image:1ni1.gif|left|200px]]
[[Image:1ni1.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ni1 |SIZE=350|CAPTION= <scene name='initialview01'>1ni1</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1ni1", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2C5:2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)-+METHOXYMETHYL]-NICOTINONITRILE'>2C5</scene>, <scene name='pdbligand=HFP:ALPHA-HYDROXYFARNESYLPHOSPHONIC+ACID'>HFP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= FNTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), FNTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_1ni1| PDB=1ni1 | SCENE= }}
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|RELATEDENTRY=[[1n9a|1N9A]], [[1n95|1N95]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ni1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ni1 OCA], [http://www.ebi.ac.uk/pdbsum/1ni1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ni1 RCSB]</span>
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}}
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'''Imidazole and cyanophenyl farnesyl transferase inhibitors'''
'''Imidazole and cyanophenyl farnesyl transferase inhibitors'''
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[[Category: Wang, W.]]
[[Category: Wang, W.]]
[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
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[[Category: cyanophenyl]]
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[[Category: Cyanophenyl]]
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[[Category: ftase]]
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[[Category: Ftase]]
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[[Category: prenyltransferase]]
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[[Category: Prenyltransferase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:33:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:30:39 2008''
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Revision as of 23:33, 2 May 2008

Image:1ni1.gif

Template:STRUCTURE 1ni1

Imidazole and cyanophenyl farnesyl transferase inhibitors


Overview

A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.

About this Structure

1NI1 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability., Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4. PMID:12699757 Page seeded by OCA on Sat May 3 02:33:26 2008

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OCA

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