8eml
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Gsx2 Homeodomain in Complex with DNA== | |
| - | + | <StructureSection load='8eml' size='340' side='right'caption='[[8eml]], [[Resolution|resolution]] 2.21Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8eml]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EML FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> |
| - | [[Category: Kovall | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eml OCA], [https://pdbe.org/8eml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eml RCSB], [https://www.ebi.ac.uk/pdbsum/8eml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eml ProSAT]</span></td></tr> |
| - | [[Category: Webb | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GSX2_MOUSE GSX2_MOUSE] Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development (PubMed:7619729). During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons (PubMed:19709628).<ref>PMID:19709628</ref> <ref>PMID:7619729</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Kovall RA]] | ||
| + | [[Category: Webb JA]] | ||
Revision as of 14:04, 18 October 2023
Crystal Structure of Gsx2 Homeodomain in Complex with DNA
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