8qkt
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Structure of a nucleosome composed of a palindromic 167-base pair blunt-ended DNA fragment== | |
- | + | <StructureSection load='8qkt' size='340' side='right'caption='[[8qkt]], [[Resolution|resolution]] 3.26Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[8qkt]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QKT FirstGlance]. <br> | |
- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.261Å</td></tr> | |
- | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
- | [[Category: Davey | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qkt OCA], [https://pdbe.org/8qkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qkt RCSB], [https://www.ebi.ac.uk/pdbsum/8qkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qkt ProSAT]</span></td></tr> |
- | [[Category: Ma | + | </table> |
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Homo sapiens]] | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Synthetic construct]] | ||
+ | [[Category: Davey CA]] | ||
+ | [[Category: Ma Z]] |
Current revision
Structure of a nucleosome composed of a palindromic 167-base pair blunt-ended DNA fragment
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