8qkt

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m (Protected "8qkt" [edit=sysop:move=sysop])
Current revision (14:12, 18 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8qkt is ON HOLD
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==Structure of a nucleosome composed of a palindromic 167-base pair blunt-ended DNA fragment==
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<StructureSection load='8qkt' size='340' side='right'caption='[[8qkt]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
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Authors: Ma, Z., Davey, C.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8qkt]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QKT FirstGlance]. <br>
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Description: Structure of a nucleosome composed of a palindromic 167-base pair blunt-ended DNA fragment
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.261&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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[[Category: Davey, C.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qkt OCA], [https://pdbe.org/8qkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qkt RCSB], [https://www.ebi.ac.uk/pdbsum/8qkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qkt ProSAT]</span></td></tr>
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[[Category: Ma, Z]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Davey CA]]
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[[Category: Ma Z]]

Current revision

Structure of a nucleosome composed of a palindromic 167-base pair blunt-ended DNA fragment

PDB ID 8qkt

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