1nih

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[[Image:1nih.gif|left|200px]]
[[Image:1nih.gif|left|200px]]
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{{Structure
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|PDB= 1nih |SIZE=350|CAPTION= <scene name='initialview01'>1nih</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1nih", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HNI:PROTOPORPHYRIN+IX+CONTAINING+NI(II)'>HNI</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>
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{{STRUCTURE_1nih| PDB=1nih | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nih OCA], [http://www.ebi.ac.uk/pdbsum/1nih PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nih RCSB]</span>
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'''Structure of deoxy-quaternary haemoglobin with liganded beta subunits'''
'''Structure of deoxy-quaternary haemoglobin with liganded beta subunits'''
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[[Category: Liddington, B.]]
[[Category: Liddington, B.]]
[[Category: Luisi, B.]]
[[Category: Luisi, B.]]
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[[Category: oxygen transport]]
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[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:34:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:30:51 2008''
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Revision as of 23:34, 2 May 2008

Template:STRUCTURE 1nih

Structure of deoxy-quaternary haemoglobin with liganded beta subunits


Overview

We have determined the structure of a T-state haemoglobin in which the haem groups of the beta subunits have carbon monoxide bound, and the alpha subunits have nickel replacing the haem iron and are ligand-free. The structural adjustments on binding ligand in the T state are in the same direction as those associated with the quaternary transition, and a translational shift of the haem is severely restricted. We explain how these observations may account for the low ligand affinity of the beta haem of T-state haemoglobin.

About this Structure

1NIH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of deoxy-quaternary haemoglobin with liganded beta subunits., Luisi B, Liddington B, Fermi G, Shibayama N, J Mol Biol. 1990 Jul 5;214(1):7-14. PMID:2370669 Page seeded by OCA on Sat May 3 02:34:31 2008

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