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6whh

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<StructureSection load='6whh' size='340' side='right'caption='[[6whh]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='6whh' size='340' side='right'caption='[[6whh]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6whh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WHH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WHH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6whh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WHH FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR41, MSTP048 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6whh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6whh OCA], [http://pdbe.org/6whh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6whh RCSB], [http://www.ebi.ac.uk/pdbsum/6whh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6whh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6whh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6whh OCA], [https://pdbe.org/6whh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6whh RCSB], [https://www.ebi.ac.uk/pdbsum/6whh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6whh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/WDR41_HUMAN WDR41_HUMAN]] Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).<ref>PMID:27103069</ref> <ref>PMID:27193190</ref> <ref>PMID:27617292</ref> <ref>PMID:28195531</ref>
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[https://www.uniprot.org/uniprot/WDR41_HUMAN WDR41_HUMAN] Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).<ref>PMID:27103069</ref> <ref>PMID:27193190</ref> <ref>PMID:27617292</ref> <ref>PMID:28195531</ref>
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Halabelian, L]]
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[[Category: Halabelian L]]
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[[Category: Hutchinson, A]]
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[[Category: Hutchinson A]]
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[[Category: Li, Y]]
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[[Category: Li Y]]
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[[Category: Structural genomic]]
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[[Category: Seitova A]]
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[[Category: Seitova, A]]
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[[Category: Protein binding]]
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[[Category: Sgc]]
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[[Category: Wd-repeat]]
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[[Category: Wdr41]]
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Revision as of 14:25, 18 October 2023

Crystal structure of human WDR41

PDB ID 6whh

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