6wko

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Current revision (14:29, 18 October 2023) (edit) (undo)
 
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<StructureSection load='6wko' size='340' side='right'caption='[[6wko]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6wko' size='340' side='right'caption='[[6wko]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6wko]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Incjh Incjh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WKO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wko]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_C_virus_(C/Johannesburg/1/66) Influenza C virus (C/Johannesburg/1/66)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WKO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.401&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HEF, HE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=100673 INCJH])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sialate_O-acetylesterase Sialate O-acetylesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.53 3.1.1.53] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wko OCA], [https://pdbe.org/6wko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wko RCSB], [https://www.ebi.ac.uk/pdbsum/6wko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wko ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wko OCA], [https://pdbe.org/6wko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wko RCSB], [https://www.ebi.ac.uk/pdbsum/6wko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wko ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A8E060_INCJH A8E060_INCJH]] Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.[ARBA:ARBA00003638][HAMAP-Rule:MF_04072][RuleBase:RU362095]
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[https://www.uniprot.org/uniprot/HEMA_INCJH HEMA_INCJH] Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Incjh]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sialate O-acetylesterase]]
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[[Category: Lee JE]]
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[[Category: Lee, J E]]
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[[Category: Serrao VHB]]
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[[Category: Serrao, V H.B]]
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[[Category: Fusion intermediate]]
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[[Category: Hemagglutinin-esterase-fusion]]
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[[Category: Influenza c virus]]
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[[Category: Viral fusion]]
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[[Category: Viral protein]]
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Current revision

Structure of an influenza C virus hemagglutinin-esterase-fusion (HEF2) intermediate

PDB ID 6wko

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