6wnx

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==FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide==
==FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide==
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<StructureSection load='6wnx' size='340' side='right'caption='[[6wnx]]' scene=''>
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<StructureSection load='6wnx' size='340' side='right'caption='[[6wnx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WNX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WNX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wnx]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WNX FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wnx OCA], [http://pdbe.org/6wnx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wnx RCSB], [http://www.ebi.ac.uk/pdbsum/6wnx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wnx ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wnx OCA], [https://pdbe.org/6wnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wnx RCSB], [https://www.ebi.ac.uk/pdbsum/6wnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wnx ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FBW1B_HUMAN FBW1B_HUMAN] Non-specific syndromic intellectual disability. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/FBW1B_HUMAN FBW1B_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).<ref>PMID:10321728</ref> <ref>PMID:10437795</ref> <ref>PMID:10644755</ref> <ref>PMID:10648623</ref> <ref>PMID:14532120</ref> <ref>PMID:14603323</ref> <ref>PMID:15917222</ref> <ref>PMID:18575781</ref> <ref>PMID:19966869</ref> <ref>PMID:20347421</ref> <ref>PMID:25503564</ref> <ref>PMID:29420262</ref> (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.<ref>PMID:19730691</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith CH]]

Revision as of 14:31, 18 October 2023

FBXW11-SKP1 in complex with a pSer33/pSer37 Beta-Catenin peptide

PDB ID 6wnx

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