6wnz
From Proteopedia
(Difference between revisions)
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==Structure of a dimer of the Sulfolobus solfataricus MCM N-terminal domain reveals potential role in MCM ring opening== | ==Structure of a dimer of the Sulfolobus solfataricus MCM N-terminal domain reveals potential role in MCM ring opening== | ||
| - | <StructureSection load='6wnz' size='340' side='right'caption='[[6wnz]]' scene=''> | + | <StructureSection load='6wnz' size='340' side='right'caption='[[6wnz]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WNZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6wnz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WNZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wnz OCA], [https://pdbe.org/6wnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wnz RCSB], [https://www.ebi.ac.uk/pdbsum/6wnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wnz ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wnz OCA], [https://pdbe.org/6wnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wnz RCSB], [https://www.ebi.ac.uk/pdbsum/6wnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wnz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCM_SACS2 MCM_SACS2] Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits.<ref>PMID:11821426</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Saccharolobus solfataricus P2]] | ||
[[Category: Enemark EJ]] | [[Category: Enemark EJ]] | ||
[[Category: Meagher M]] | [[Category: Meagher M]] | ||
[[Category: Spence MN]] | [[Category: Spence MN]] | ||
Current revision
Structure of a dimer of the Sulfolobus solfataricus MCM N-terminal domain reveals potential role in MCM ring opening
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