6xfq
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ==== | + | ==Structure of a novel antithrombotic agent Agkisacucetin in complex with the platelet glycoprotein Ib receptor== |
| - | <StructureSection load='6xfq' size='340' side='right'caption='[[6xfq]]' scene=''> | + | <StructureSection load='6xfq' size='340' side='right'caption='[[6xfq]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xfq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XFQ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xfq OCA], [https://pdbe.org/6xfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xfq RCSB], [https://www.ebi.ac.uk/pdbsum/6xfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xfq ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xfq OCA], [https://pdbe.org/6xfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xfq RCSB], [https://www.ebi.ac.uk/pdbsum/6xfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xfq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SLB2_DEIAC SLB2_DEIAC] Agglucetin specifically causes platelet aggregation and surface exposure of integrin alpha-IIb/beta-3 with a GPIb-(GP1BA-) dependent manner in washed platelets. It binds to human platelets in a saturable manner, and its binding is specifically blocked by anti-GP Ib mAb. It regulates endothelial cell survival and promotes angiogenesis by activating integrin alpha-v/beta-3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway.<ref>PMID:11686327</ref> <ref>PMID:18312855</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Platelet glycoprotein|Platelet glycoprotein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Deinagkistrodon acutus]] | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Gao YX]] |
| + | [[Category: Ke JY]] | ||
| + | [[Category: Niu LW]] | ||
| + | [[Category: Wang J]] | ||
| + | [[Category: Zhu ZL]] | ||
Revision as of 14:51, 18 October 2023
Structure of a novel antithrombotic agent Agkisacucetin in complex with the platelet glycoprotein Ib receptor
| |||||||||||
Categories: Deinagkistrodon acutus | Homo sapiens | Large Structures | Gao YX | Ke JY | Niu LW | Wang J | Zhu ZL
