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6xnj

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Current revision (14:57, 18 October 2023) (edit) (undo)
 
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==Crystal structure of the PDZ domain of human GOPC in complex with a peptide of E. coli O157:H7 str. Sakai effector NleG8==
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<StructureSection load='6xnj' size='340' side='right'caption='[[6xnj]]' scene=''>
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<StructureSection load='6xnj' size='340' side='right'caption='[[6xnj]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6xnj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7_str._Sakai Escherichia coli O157:H7 str. Sakai] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XNJ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xnj OCA], [http://pdbe.org/6xnj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xnj RCSB], [http://www.ebi.ac.uk/pdbsum/6xnj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xnj ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xnj OCA], [https://pdbe.org/6xnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xnj RCSB], [https://www.ebi.ac.uk/pdbsum/6xnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xnj ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Escherichia coli O157:H7 str. Sakai]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Chang C]]
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[[Category: Joachimiak A]]
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[[Category: Popov G]]
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[[Category: Satchell KJF]]
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[[Category: Savchenko A]]
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[[Category: Skarina T]]
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[[Category: Stogios PJ]]

Current revision

Crystal structure of the PDZ domain of human GOPC in complex with a peptide of E. coli O157:H7 str. Sakai effector NleG8

PDB ID 6xnj

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